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European Heart Journal 1995 16(7):961-966;
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

Application of ultrasound energy for intracardiac ablation of arrhythmias

D. S. HE*, J. E. ZIMMER{dagger}, K. HYNYNEN{dagger}, F. I. CARCUS*, A. C. CARUSO*, L. F. LAMPE* and M. L. AGUIRRE{ddagger}

*From the, Cardiology Section, Department of Medicine, University of Arizona, College of Medicine Tucson, Arizona, U.S.A
{dagger}From the, Department of Radiation Oncology, University of Arizona, College of Medicine Tucson, Arizona, U.S.A
{ddagger}From the, Department of Pathology, University of Arizona, College of Medicine Tucson, Arizona, U.S.A

revised 14 October 1994; accepted 28 October 1994.

Correspondence: Frank I. Carcus, MD, Cardiology Section, University of Arizona Health Sciences Center, 1501 North Campbell Avenue, Tucson, Arizona 85724, U.S.A.

Abstract

Ultrasound is a potential energy source for cardiac ablation. Small ultrasound applicators were tested for their ability to create lesions in cardiac tissue. Ultrasound applicators were designed, constructed and tested in canine cardiac tissue in degassed normal saline, and both in vitro and in vivo, lesions were produced by using transducers with frequencies of about 10 MHz. Lesion depth increased with longer duration of energy delivery from 15–60 s, and there was a linear relationship between increasing power and depth of lesions. Seven in vivo experiments in open-chest dogs were performed, and the ultrasound transducers were mounted on the tip of 7-French angiographic catheters. On the epicardium the maximum lesion depth was 9 mm. When the transducer was inserted into the left ventricle, lesions of 8.7 ± 2.9 mm (n={theta}4) were produced. It is concluded that an ultrasound transducer mounted on a cardiac catheter can produce lesions that may be useful for ablation of cardiac arrhythmias.

Key Words: Catheter ablation • ultrasound • arthythmias


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